The Naltrexone Handbook

One molecule. Two doses. Two entirely different stories. At 50 mg, naltrexone is one of the best supported medications in addiction medicine. At a tenth of that dose, it has become the most discussed off-label option in chronic illness, championed by people with something to sell and refused by doctors who rarely explain why. Somewhere between the promise and the refusal is the thing nobody hands you: the actual evidence, including the parts that do not help. This handbook grades every use of naltrexone by the strength of the studies behind it. It reports the trials that worked and the trial that missed. It covers what the drug does at each dose, how to read the research yourself, how to get hold of a medicine no factory makes, how to find your dose when no target dose has ever been established, why an opioid antagonist in your kitchen matters to a paramedic, and how to hold the conversation that decides whether you get a prescription at all. It will not tell you that naltrexone will help you. Nobody honest can. It will tell you exactly what is known, what is contested, and what is still unsettled, so that when you decide, the decision is yours and you know what you are holding. Fourteen chapters. Six working appendices. 101 verified sources. No sales pitch.